ACCeSS

Selection and optimization of cyanobacterial and cyanidialic strains for optimal growth and CO2 fixation in i) well controllable lab-scale photobioreactors, and ii) large scale prototype reactors by synthetic biology and environmental mining approach.

Project leaders:
Ilka Axmann, Institute for Synthetic Microbiology , HHU; Send
Andreas Weber, Institute of Plant Biochemistry , HHU; Send

Protein-engineering of an artificial enzyme cascade and metabolic engineering of Cupriavidus necator for the fixation of CO2 with H2 as an electron donor (reducing agent). Evaluation of the here and in other APs developed CO2 fixation systems based on their economic feasibility and environmental impact.

Researcher: Dr. Elisabeth Lettau; Send

Project leaders:
Lars Lauterbach, Institute of Applied Microbiology, RWTH Aachen; Send
Grit Walther, Chair of Operations Management, RWTH Aachen; Send

Optimization of membrane transport systems in cyanobacteria and Galdieria for the uptake of nutrients, including CO2 as carbon source, and for the export of carbohydrates and secretion of exopolysaccharide. Investigation and testing of metal ion exporters to allow the growth in heavy metal contaminated wastewater.

Projects leaders:
Ulrich Schwaneberg, Chair of Biotechnology, RWTH Aachen; Send
Andrij Pich, Chair of Functional and Interactive Polymers, RWTH Aachen; Send

Optimization of membrane transport systems in cyanobacteria and Galdieria for the uptake of nutrients, including CO₂ as carbon source, and for the export of carbohydrates and secretion of exopolysaccharide. Investigation and testing of metal ion exporters to allow the growth in heavy metal contaminated wastewater.

Researcher: Dr. Zoreh Pourhassan; Send

Project leaders:
Lutz Schmitt, Institute of Biochemistry, HHU; Send
Andreas Weber, Institute of Plant Biochemistry, HHU; Send

Identification and classification of proteases, hydrolases, cell wall synthesizing and degrading enzymes by in depth analyzation of the genomes of red algae with novel deep learning tools and by measuring and analyzing of RNA-data based expression profiles. In depth computational analysis of enzymes, which are estimated to improve biomass production and its utilization, to allow future bioengineering campaigns.

Project leaders:
Holger Gohlke, Institute of Bio- and Geosciences (IBG), Structure Based Bioinformatics (IBG-4), FZ Jülich; Send
Björn Usadel, Institute of Bio- and Geosciences (IBG), Omics-/Data-based Bioinformatics (IBG-4), FZ Jülich; Send

Development of strategies to produce Gladeria strains with altered cell wall properties by in depth analyzation of the composition of the Galderia cell wall and its biosynthesis. Testing of strains producing enhanced cell walls as plaster wall material source and cell wall degrading strains, controlled by optogenetics, as improved feed stock. In vitro expression and analysis of degrading enzymes identified in project 5.

Project leaders:
Vlada Urlacher, Institute of Biochemistry II, HHU; Send
Markus Pauly, Institute for Plant Cell Biology and Biotechnology, HHU; Send
Jörg Pietruszka, Institute of Bioorganic Chemistry, HHU; Send
Matias Zurbriggen, Institute of Synthetic Biology, HHU; Send

Establishment of optimized harvesting and processing procedures to utilize the by Galdieria or cyanobacteria produced biomass as a feed stock for heterotroph organisms producing valuable products. Development of strategies to directly produce products from cocultures of Galdieria/cyanobacteria and selected heterotrophs.

Project leaders:
Julia Frunzke, Institute of Bio- and Geosciences, Biotechnology (IBG-1), Bacterial Networks and Interactions, FZ Jülich; Send
Michael Feldbrügge, Institute of Microbiology, HHU; Send

Incorporation and optimization of carbohydrate transporter systems and of artificial pathways to couple those carbohydrates to the central metabolism in heterotroph organisms for improved growth on biomass produced by Galdieria or cyanobacteria.

Researcher: Dr. Tim Kroll; Send

Project leaders:
Alexej Kedrov, Institute for Synthetic Mebrane Systems, HHU; Send
Lutz Schmitt, Institute of Biochemistry, HHU; Send
Ulrich Schwaneberg, Institute of Biotechnology, RWTH Aachen; Send

Implementation of strategies to make the scientific method and its results more accessible to non-scientist and thereby strengthening the exchange between scientist and non-scientist to reestablish confidence of the public into academic research.

Researcher: Dr. Maria Sojka; Send

Project leaders:
Gottfried Vosgerau, Institute for Philosophy VI, Philosophy of Mind, HHU; Send
Michael Schmitt, High Resolution Molecular Spectroscopy, HHU; Send